Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 12/20 | 0.60 |
| ▸ | GSK3B | P49841 | 7/20 | 0.60 |
| ▸ | NFATC1 | O95644 | 4/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.47 |
| ▸ | PIM1 | P11309 | 3/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | GRK5 | P34947 | 1/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13051144 | 0.85 | DYRK1A (0.60) | DYRK1AGSK3BNFATC1DYRK1BPIM1 | |
| SCHEMBL13051111 | 0.85 | DYRK1A (0.62) | DYRK1AGSK3BNFATC1DYRK1BPIM1 | |
| SCHEMBL13051149 | 0.85 | DYRK1A (0.56) | DYRK1AGSK3BNFATC1DYRK1BPIM1 | |
| SCHEMBL13051145 | 0.83 | DYRK1A (0.57) | DYRK1AGSK3BNFATC1DYRK1BPIM1 | |
| SCHEMBL13051138 | 0.82 | DYRK1A (0.65) | DYRK1AGSK3BNFATC1DYRK1BPIM1 | |
| SCHEMBL13051139 | 0.81 | DYRK1A (0.64) | DYRK1AGSK3BNFATC1HSP90AA1HSP90AB1 | |
| SCHEMBL13051148 | 0.81 | DYRK1A (0.57) | DYRK1AGSK3BNFATC1DYRK1BPIM1 | |
| SCHEMBL13051140 | 0.79 | DYRK1A (0.57) | DYRK1AGSK3BNFATC1DYRK1BPIM1 | |
| SCHEMBL13051143 | 0.79 | DYRK1A (0.57) | DYRK1AGSK3BNFATC1DYRK1BPIM1 | |
| SCHEMBL3657990 | 0.78 | DYRK1A (0.60) | DYRK1AGSK3BNFATC1DYRK1BPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292262-A1 | 4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-11-18 | — | — | US | disclosed |
| US-20100292262-A1 | 4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-11-18 | — | — | US | disclosed |
| WO-2009092431-A1 | 4-(PYRROLO[2,3-C]PYRIDINE-3-YL)-PYRIMIDINE-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292262-A1 | 4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES | MKI67, CDK4, CCNT1 | DYRK1A 2428/4885GSK3B 1642/4885NFATC1 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.