Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.54 |
| ▸ | GSK3A | P49840 | 2/20 | 0.54 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 14/20 | 0.46 |
| ▸ | SRC | P12931 | 8/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.45 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.44 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13925100 | 0.85 | ULK1 (0.48) | GSK3BSRCAURKBNTRK1 | |
| SCHEMBL13054452 | 0.83 | AURKA (0.70) | GSK3BGSK3AAURKASRCAURKB | |
| SCHEMBL13054547 | 0.83 | GRM4 (0.43) | SLC2A1AURKAMEN1MAPTRAB9A | |
| SCHEMBL13601862 | 0.82 | GSK3B (0.56) | GSK3BGSK3ASLC2A1AURKASRC | |
| SCHEMBL13054762 | 0.82 | GSK3B (0.52) | GSK3BGSK3AAURKASRCAURKB | |
| SCHEMBL13054730 | 0.82 | GSK3B (0.52) | GSK3BGSK3AAURKASRCAURKB | |
| SCHEMBL14423488 | 0.82 | GSK3B (0.52) | GSK3BGSK3AAURKASRCAURKB | |
| SCHEMBL13054909 | 0.79 | GSK3B (0.49) | GSK3BGSK3AAURKASRCAURKB | |
| SCHEMBL13054516 | 0.78 | AURKA (0.49) | GSK3BGSK3AAURKASRCAURKB | |
| SCHEMBL13054542 | 0.78 | AURKA (0.45) | AURKAAURKBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842712-B2 | Indazolinone compositions useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-30 | — | — | US | disclosed |
| US-7842712-B2 | Indazolinone compositions useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-30 | — | — | US | disclosed |
| US-7262200-B2 | Indazolinone compositions useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-08-28 | — | — | US | disclosed |
| US-7262200-B2 | Indazolinone compositions useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-08-28 | — | — | US | disclosed |