Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 6/20 | 1.00 |
| ▸ | PTPN7 | P35236 | 13/20 | 0.77 |
| ▸ | HSPA1A | P0DMV8 | 8/20 | 0.77 |
| ▸ | HSPA8 | P11142 | 6/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.77 |
| ▸ | GAPDH | P04406 | 6/20 | 0.77 |
| ▸ | POLB | P06746 | 6/20 | 0.77 |
| ▸ | MEN1 | O00255 | 6/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.77 |
| ▸ | BLM | P54132 | 5/20 | 0.77 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.77 |
| ▸ | MAPT | P10636 | 4/20 | 0.77 |
| ▸ | RECQL | P46063 | 4/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.77 |
| ▸ | HPGD | P15428 | 3/20 | 0.77 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.77 |
| ▸ | DUSP1 | P28562 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2117400 | 0.87 | PTPN7 (1.00) | NR4A1PTPN7HSPA1AHSPA8TDP1 | |
| SCHEMBL13856742 | 0.87 | PTPN7 (1.00) | NR4A1PTPN7HSPA1AHSPA8TDP1 | |
| SCHEMBL2116061 | 0.78 | PTPN7 (1.00) | NR4A1PTPN7HSPA1AHSPA8TDP1 | |
| SCHEMBL14758490 | 0.77 | CDC25B (1.00) | NR4A1PTPN7HSPA1AHSPA8TDP1 | |
| SCHEMBL14680373 | 0.77 | PTPN7 (1.00) | NR4A1PTPN7HSPA1AHSPA8TDP1 | |
| SCHEMBL2804418 | 0.77 | CDC25B (1.00) | NR4A1PTPN7HSPA1AHSPA8TDP1 | |
| SCHEMBL13056448 | 0.77 | PTPN7 (1.00) | NR4A1PTPN7HSPA1AHSPA8TDP1 | |
| SCHEMBL2117317 | 0.77 | PTPN7 (1.00) | NR4A1PTPN7HSPA1AHSPA8TDP1 | |
| SCHEMBL13726071 | 0.75 | PTPN7 (1.00) | NR4A1PTPN7HSPA1AHSPA8TDP1 | |
| SCHEMBL13726075 | 0.75 | CDC25B (0.76) | NR4A1PTPN7HSPA1AHSPA8TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | BURHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-02 | — | — | US | disclosed |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | UNITED STATES GOVERNMENT | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | FADS2, ACOT7, FADS1 | NR4A1 4269/4885PTPN7 3916/4885HSPA1A 4515/4885 |
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | FADS2, ACOT7, FADS1 | NR4A1 4269/4885PTPN7 3916/4885HSPA1A 4515/4885 |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | BCL2, BAX, BAD | NR4A1 4082/4885PTPN7 3199/4885HSPA1A 535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.