Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13005624 | 0.92 | MAPK1 (0.46) | MAPTMEN1KMT2AMAPK1NPSR1 | |
| SCHEMBL10364099 | 0.79 | SMN1; SMN2 (0.60) | MAPTMEN1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL13060853 | 0.77 | HDAC4 (0.45) | HDAC4 | |
| SCHEMBL13061119 | 0.77 | HDAC4 (0.45) | HDAC4 | |
| SCHEMBL13779842 | 0.77 | CA12 (0.64) | MAPTMEN1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL13005674 | 0.75 | SMN1; SMN2 (0.46) | RAB9ASMN1; SMN2NPC1GAAALOX15 | |
| SCHEMBL15601909 | 0.75 | MAPT (0.53) | MAPTMEN1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL13061112 | 0.73 | NISCH (0.35) | MEN1KMT2A | |
| SCHEMBL13061084 | 0.73 | NISCH (0.35) | MEN1KMT2A | |
| SCHEMBL14405803 | 0.72 | MAPT (0.62) | MAPTMEN1RAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |