Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.45 |
| ▸ | NPY1R | P25929 | 2/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13061126 | 0.86 | NPC1 (0.54) | EPHX1EPHX2NPC1RAB9A | |
| SCHEMBL13005689 | 0.83 | NPY5R (0.48) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13005624 | 0.82 | MAPK1 (0.46) | — | |
| SCHEMBL13005671 | 0.81 | F2 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13005589 | 0.78 | KMT2A (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13061130 | 0.75 | MAPT (0.48) | SMN1; SMN2NPC1RAB9AALOX15GAA | |
| SCHEMBL13061039 | 0.72 | SMN1; SMN2 (0.52) | SMN1; SMN2EPHX2F2RL1NPY5RNPC1 | |
| SCHEMBL13256338 | 0.71 | CTSL (0.46) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13060826 | 0.71 | CTSL (0.44) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13005597 | 0.70 | ALDH1A1 (0.42) | SMN1; SMN2PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |