Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | METAP1 | P53582 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2126347 | 0.85 | NPC1 (0.54) | NPC1KDM4EMETAP1RAB9AL3MBTL1 | |
| SCHEMBL2712438 | 0.85 | NPC1 (0.54) | NPC1KDM4EMETAP1RAB9AL3MBTL1 | |
| SCHEMBL3782688 | 0.85 | KDM4E (0.54) | NPC1KDM4EMETAP1RAB9AL3MBTL1 | |
| SCHEMBL27866931 | 0.82 | NPC1 (0.50) | NPC1KDM4EMETAP1RAB9AL3MBTL1 | |
| SCHEMBL2855425 | 0.80 | KDM4E (0.55) | NPC1KDM4EMETAP1RAB9AL3MBTL1 | |
| SCHEMBL14084546 | 0.79 | NPC1 (0.54) | NPC1KDM4EMETAP1RAB9AL3MBTL1 | |
| SCHEMBL2061612 | 0.77 | KDM4E (0.70) | NPC1KDM4EMETAP1RAB9AL3MBTL1 | |
| SCHEMBL8018580 | 0.77 | KDM4E (0.65) | NPC1KDM4EMETAP1RAB9AL3MBTL1 | |
| SCHEMBL6509452 | 0.77 | KDM4E (0.55) | NPC1KDM4EMETAP1RAB9AL3MBTL1 | |
| SCHEMBL12925935 | 0.76 | CYP1A2 (0.55) | NPC1KDM4ERAB9AL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331293-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331293-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, MALT1, BCL9 | NPC1 4409/4885KDM4E 2124/4885METAP1 4171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.