Sugi Predict

Sugi Predict / Compounds / SCHEMBL2855425

SCHEMBL2855425

SCHEMBL2855425

c1ccc(-c2nc3ccccc3c3ccccc23)nc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 6/20 0.55
▸ NPC1 O15118 5/20 0.55
▸ METAP1 P53582 5/20 0.53
▸ ALDH1A1 P00352 4/20 0.50
▸ RAB9A P51151 4/20 0.50
▸ LMNA P02545 3/20 0.50
▸ HIF1A Q16665 2/20 0.50
▸ HTT P42858 2/20 0.50
▸ L3MBTL1 Q9Y468 2/20 0.50
▸ GAA P10253 1/20 0.50
▸ POLB P06746 2/20 0.48
▸ CCR1 P32246 2/20 0.48
▸ CCR5 P51681 2/20 0.48
▸ CCR8 P51685 2/20 0.48
▸ CYP1A2 P05177 2/20 0.48
▸ BLM P54132 1/20 0.48
▸ DOHH Q9BU89 1/20 0.48
▸ P4HTM Q9NXG6 1/20 0.48
▸ MAPT P10636 1/20 0.47
▸ LRRK2 Q5S007 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22761534 0.82 GPR3 (0.48) KDM4EALDH1A1RAB9ALMNAHIF1A
SCHEMBL2061612 0.81 KDM4E (0.70) KDM4ENPC1METAP1ALDH1A1RAB9A
SCHEMBL13063628 0.80 NPC1 (0.59) KDM4ENPC1METAP1ALDH1A1RAB9A
SCHEMBL3779006 0.80 METAP1 (0.57) KDM4ENPC1METAP1ALDH1A1RAB9A
SCHEMBL367849 0.80 ADORA2A (0.61) KDM4ENPC1METAP1ALDH1A1RAB9A
SCHEMBL24589754 0.80 KMT2A (0.57) KDM4ENPC1METAP1ALDH1A1RAB9A
SCHEMBL14084546 0.80 NPC1 (0.54) KDM4ENPC1METAP1ALDH1A1RAB9A
SCHEMBL17034862 0.80 NPC1 (0.46) KDM4ENPC1METAP1ALDH1A1RAB9A
SCHEMBL12578108 0.80 DHODH (0.46) KDM4ENPC1METAP1ALDH1A1RAB9A
SCHEMBL23098944 0.79 NPC1 (0.46) KDM4ENPC1METAP1ALDH1A1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023182835-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT ELEMENT USING SAME 솔루스첨단소재 주식회사 2023-09-28 — — WO disclosed
US-9273002-B2 Benzo[k]fluoranthene derivative and organic electroluminescence device containing the same IDEMITSU KOSAN CO., LTD. (JP) 2016-03-01 — — US disclosed
US-9273002-B2 Benzo[k]fluoranthene derivative and organic electroluminescence device containing the same IDEMITSU KOSAN CO., LTD. (JP) 2016-03-01 — — US disclosed
EP-2626346-A1 BENZO[K]FLUORANTHENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE ELEMENT CONTAINING SAME Idemitsu Kosan Co., Ltd. (JP) 2013-08-14 — — EP disclosed
US-20120211743-A1 BENZO[k]FLUORANTHENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE CONTAINING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2012-08-23 — — US disclosed
US-20120211743-A1 BENZO[k]FLUORANTHENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE CONTAINING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2012-08-23 — — US disclosed
EP-1846390-B1 NOVEL 6-PYRIDYLPHENANTHRIDINES NYCOMED GMBH (DE) 2010-03-17 — — EP disclosed
US-20080167316-A1 6-Heteroaryl-1,2,3,4,4A, 10B-Hexahydrophenanthridines as Pde4-Inhibitors for the Treatment of Inflammatory Disorders ALTANA PHARMA AG (DE) 2008-07-10 — — US disclosed
US-20080119505-A1 Novel 6-Pyridylphenanthridines ALTANA PHARMA AG (DE) 2008-05-22 — — US disclosed
US-20080119505-A1 Novel 6-Pyridylphenanthridines ALTANA PHARMA AG (DE) 2008-05-22 — — US disclosed
EP-1147088-A1 6-ARYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 2001-10-24 — — EP disclosed
EP-1147087-A1 PHENANTHRIDINE-N-OXIDES WITH PDE-IV INHIBITING ACTIVITY Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 2001-10-24 — — EP disclosed
EP-1147103-A1 PHENANTRHRIDINE-N-OXIDES WITH PDE-IV INHIBITING ACTIVITY Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 2001-10-24 — — EP disclosed
EP-1147089-A1 PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 2001-10-24 — — EP disclosed
WO-2001051470-A1 PHENANTHRIDINE-N-OXIDES BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 2001-07-19 — — WO disclosed
WO-2000042020-A1 PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 2000-07-20 — — WO disclosed
WO-2000042017-A1 PHENANTHRIDINE-N-OXIDES WITH PDE-IV INHIBITING ACTIVITY BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 2000-07-20 — — WO disclosed
WO-2000042019-A1 6-ARYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 2000-07-20 — — WO disclosed
WO-2000042018-A1 POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 2000-07-20 — — WO disclosed
WO-2000042034-A1 PHENANTHRIDINE-N-OXIDES WITH PDE-IV INHIBITING ACTIVITY BYK GULDEN (DE) 2000-07-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080119505-A1 Novel 6-Pyridylphenanthridines PDE4A, PDE4B, PDE4C KDM4E 1002/4885NPC1 4550/4885METAP1 2391/4885
US-20080167316-A1 6-Heteroaryl-1,2,3,4,4A, 10B-Hexahydrophenanthridines as Pde4-Inhibitors for the Treatment of Inflammatory Disorders PDE4A, PDE4B, PDE4C KDM4E 958/4885NPC1 3082/4885METAP1 2236/4885
US-20120211743-A1 BENZO[k]FLUORANTHENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE CONTAINING THE SAME KCNJ2, KCNE1, KCNK2 KDM4E 764/4885NPC1 3587/4885METAP1 4765/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.