Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 14/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.37 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.37 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3784573 | 0.85 | MAP2K1 (0.46) | MAP2K1MAP2K2CA2HDAC3HDAC4 | |
| SCHEMBL3794912 | 0.82 | MAP2K1 (0.41) | MAP2K1MAP2K2CA2PIM1CAMK2B | |
| SCHEMBL13063566 | 0.80 | MAP2K1 (0.56) | MAP2K1MAP2K2 | |
| SCHEMBL387833 | 0.79 | MAP2K1 (0.51) | MAP2K1MAP2K2CA2HDAC3HDAC4 | |
| SCHEMBL391574 | 0.79 | MAP2K1 (0.53) | MAP2K1MAP2K2CA2HDAC3HDAC4 | |
| SCHEMBL392673 | 0.78 | MAP2K1 (0.50) | MAP2K1MAP2K2CA2 | |
| SCHEMBL3813729 | 0.77 | MAP2K1 (0.36) | MAP2K1MAP2K2 | |
| SCHEMBL392182 | 0.77 | MAP2K1 (0.49) | MAP2K1MAP2K2CA2 | |
| SCHEMBL10251094 | 0.74 | MAP2K1 (0.48) | MAP2K1MAP2K2CA2HDAC3HDAC4 | |
| SCHEMBL387927 | 0.74 | MAP2K1 (0.44) | MAP2K1MAP2K2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |