Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 15/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3794912 | 0.87 | MAP2K1 (0.41) | MAP2K1MAP2K2CA2PIM1CAMK2B | |
| SCHEMBL13063852 | 0.85 | MAP2K1 (0.43) | MAP2K1MAP2K2CA2HDAC3HDAC4 | |
| SCHEMBL387833 | 0.78 | MAP2K1 (0.51) | MAP2K1MAP2K2CA2HDAC3HDAC4 | |
| SCHEMBL391574 | 0.78 | MAP2K1 (0.53) | MAP2K1MAP2K2CA2HDAC3HDAC4 | |
| SCHEMBL392673 | 0.77 | MAP2K1 (0.50) | MAP2K1MAP2K2CA2 | |
| SCHEMBL3795881 | 0.76 | MAP2K1 (0.52) | MAP2K1MAP2K2CA2 | |
| SCHEMBL392027 | 0.75 | MAP2K1 (0.58) | MAP2K1MAP2K2CA2PIM1CAMK2B | |
| SCHEMBL10251094 | 0.73 | MAP2K1 (0.48) | MAP2K1MAP2K2CA2HDAC3HDAC4 | |
| SCHEMBL10254679 | 0.72 | MAP2K1 (0.45) | MAP2K1MAP2K2CA2HDAC3HDAC4 | |
| SCHEMBL13063785 | 0.70 | MAP2K1 (0.56) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |