Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21495104 | 0.84 | CYP3A4 (0.38) | BTKCYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL21518211 | 0.81 | BTK (0.38) | BTKCYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL179528 | 0.78 | TAAR1 (0.42) | BTKCYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL8865877 | 0.76 | CYP3A4 (0.45) | BTKCYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL21606271 | 0.76 | TAAR1 (0.38) | BTKCYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL12915230 | 0.74 | CYP3A4 (0.38) | BTKCYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL38661913 | 0.74 | CYP3A4 (0.44) | BTKCYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL4196024 | 0.74 | CYP3A4 (0.44) | BTKCYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL38661915 | 0.74 | CYP3A4 (0.44) | BTKCYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL20738487 | 0.74 | TAAR1 (0.40) | BTKCYP3A4CYP2D6SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331341-A1 | 2-CARBOXAMIDE-7-PIPERAZINYL-BENZOFURAN DERIVATIVES 774 | ASTRAZENECA AB (SE) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331341-A1 | 2-CARBOXAMIDE-7-PIPERAZINYL-BENZOFURAN DERIVATIVES 774 | C1R, HTR4, HTR2C | BTK 1327/4885CYP3A4 14/4885CYP2D6 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.