HTR4

5-hydroxytryptamine receptor 4 · Q13639 · HTR4 on Sugi Atlas →

45,318 patent compounds predicted against HTR4, 24,361 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Felcisetrag (SCHEMBL390795)	1.00	20/20
SCHEMBL393401	1.00	20/20
SCHEMBL391205	0.82	20/20
Felcisetrag (SCHEMBL639852)	0.76	20/20
SCHEMBL218594	0.64	20/20
SCHEMBL218595	0.60	20/20
SCHEMBL599154	0.57	20/20
SCHEMBL496159	0.50	19/20
SCHEMBL535050	1.00	18/20
Piboserod (SCHEMBL572991)	0.69	18/20
Piboserod (SCHEMBL467339)	1.00	17/20
SCHEMBL724283	1.00	17/20
Hydrochloric Acid (SCHEMBL194956)	0.98	17/20
SCHEMBL593226	1.00	16/20
Pf-04995274 (SCHEMBL619629)	1.00	16/20
Pf-04995274 (SCHEMBL619630)	1.00	16/20
Hydrochloric Acid (SCHEMBL534945)	0.98	16/20
SCHEMBL678305	0.74	16/20
SCHEMBL598401	0.58	16/20
Cisapride (SCHEMBL16131)	1.00	15/20

Clinical trials — most relevant to HTR4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Relationship Among Changes in Brain Network Activation in Adult Outpatients With Major Depressive Disorder	PHASE4	COMPLETED
Reversible Effects of Oral Contraceptive Removal on Serotonergic Neurotransmission	PHASE4	NOT_YET_RECRUITING
Outcome Following Antidepressant Treatment on Possible Endo-Phenotypes for Major Depression	PHASE4	COMPLETED
Serotonin Transporter Genetic Variation and Amygdala Responses to Antidepressant Medications in Major Depression	PHASE4	COMPLETED
Monoamine Transporters Genotypes: Risk of PTSD and Related Comorbidities	PHASE3	COMPLETED
Safety and Efficacy of MEM 3454 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease	PHASE2	COMPLETED
The Effect of Ginger on the Incidence of Postoperative Nausea and Vomiting	PHASE2	COMPLETED
Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder	PHASE2	RECRUITING
Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression	PHASE1/PHASE2	RECRUITING
Brain Imaging, Genetics and Treatment for Major Depression	PHASE1	WITHDRAWN
The Neurobiological Effect of 5-HT2AR Modulation	PHASE1	RECRUITING
PF-04995274 and Emotional Processing in Treatment Resistant Depression	PHASE1	COMPLETED
PF-04995274 and Emotional Processing in Un-medicated Depression	PHASE1	COMPLETED
The Pill Project - Oral Contraceptive and Serotonergic Brain Signaling	nan	UNKNOWN
Prucalopride and Cognition in Recovered Depression	nan	COMPLETED
5-HT7 Receptor Implication in Inflammatory Mechanisms in Multiple Sclerosis	nan	COMPLETED
The Role of Sex Steroids and Serotonin Brain Dynamics in Perinatal Mental Health	nan	COMPLETED
Epigenetic and Neurochemical Correlates of Bipolar Disorder	nan	NOT_YET_RECRUITING
Investigating Serotonin Signalling in IBD Patients	nan	RECRUITING
The Role of 5-HT2A Receptor in the Perception of Self and Personal Meaning in Healthy Volunteers	nan	COMPLETED
Examination of Brain Serotonin Receptors in Patients With Mood Disorders	nan	COMPLETED
Evaluation of [11C]Cimbi-36 as an Agonist PET Radioligand for Imaging of 5-HT2A Receptors	nan	COMPLETED
Pre-Treatment Positron Emission Topography Scanning for Increasing Success in Antidepressant Treatment	nan	COMPLETED
Imaging Serotonin 5HT1A Receptors in Patients With Major Depressive Disorder	nan	WITHDRAWN
p11 Protein Levels in Patients With Major Depressive Disorder Treated With Citalopram	nan	COMPLETED
Therapeutic Outcomes of Selective Serotonin Reuptake Inhibitors and Phosphodiesterase-5 Inhibitors Combination Therapy Versus Monotherapy	nan	NOT_YET_RECRUITING
Effects of Lurasidone on Left Ventricle Systolic Functions	nan	NOT_YET_RECRUITING
Investigating the Neuropsychological Effects of 5-HT2a Antagonism	nan	RECRUITING
Trazodone and the Risk of Serious Adverse Events	nan	COMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a HTR4 binder may also engage these)

Protein	Name	Similarity
O70528	—	1.000	O70528 →
P97288	—	1.000	P97288 →
Q62758	—	1.000	Q62758 →
P18901	—	1.000	P18901 →
O42384	—	1.000	O42384 →
P50130	—	0.999	P50130 →
Q91081	—	0.999	Q91081 →
P10608	—	0.999	P10608 →
P54833	—	0.998	P54833 →
DRD1	D(1A) dopamine receptor	0.998	landscape →
O42574	—	0.998	O42574 →
P79748	—	0.998	P79748 →
Q16950	—	0.998	Q16950 →
Q8UUY8	—	0.998	Q8UUY8 →
P51046	—	0.998	P51046 →
P42288	—	0.998	P42288 →
Q95136	—	0.997	Q95136 →
Q4KWL2	—	0.997	Q4KWL2 →
P30940	—	0.997	P30940 →
P04274	—	0.997	P04274 →
DRD2	D(2) dopamine receptor	0.996	landscape →
Q28044	—	0.996	Q28044 →
G3M4F8	—	0.996	G3M4F8 →
P42290	—	0.995	P42290 →
Q9N2B6	—	0.995	Q9N2B6 →
Q5IS72	—	0.995	Q5IS72 →
Q6VB83	—	0.995	Q6VB83 →
P28564	—	0.995	P28564 →
P35404	—	0.995	P35404 →
HTR1B	5-hydroxytryptamine receptor 1B	0.994	landscape →