Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1305762 | 0.89 | MEN1 (0.45) | ADAMTS5ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL1305765 | 0.89 | MEN1 (0.45) | ADAMTS5ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL1306509 | 0.84 | KMT2A (0.43) | ADAMTS5ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL1305856 | 0.84 | HDAC6 (0.47) | ALDH1A1MEN1KMT2ATDP1USP2 | |
| SCHEMBL1305858 | 0.84 | HDAC6 (0.47) | ALDH1A1MEN1KMT2ATDP1USP2 | |
| SCHEMBL1306245 | 0.83 | HPGD (0.49) | TRPM4ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL1307208 | 0.83 | TRPM4 (0.41) | TRPM4ADAMTS5ALDH1A1MEN1KMT2A | |
| SCHEMBL1305803 | 0.83 | DHODH (0.43) | TRPM4ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL1306803 | 0.83 | HPGD (0.43) | TRPM4ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL1325518 | 0.83 | TRPM4 (0.41) | TRPM4ALDH1A1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |