Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 11/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13065413 | 1.00 | AR (0.59) | ARRXFP1KCNH2BRD4KMT2A | |
| SCHEMBL3473287 | 0.88 | AR (0.75) | ARRXFP1KCNH2BRD4DPP4 | |
| SCHEMBL3473971 | 0.88 | AR (0.75) | ARRXFP1KCNH2BRD4DPP4 | |
| SCHEMBL748810 | 0.88 | AR (0.75) | ARRXFP1KCNH2BRD4DPP4 | |
| SCHEMBL748953 | 0.86 | AR (0.71) | ARRXFP1KCNH2BRD4DPP4 | |
| SCHEMBL3475748 | 0.86 | AR (0.71) | ARRXFP1KCNH2BRD4DPP4 | |
| SCHEMBL13030810 | 0.86 | AR (0.71) | ARRXFP1KCNH2BRD4DPP4 | |
| SCHEMBL752809 | 0.74 | AR (1.00) | ARKCNH2BRD4DRD3 | |
| SCHEMBL750071 | 0.71 | AR (0.73) | ARRXFP1KCNH2BRD4DPP4 | |
| SCHEMBL13064620 | 0.70 | BRD4 (0.59) | ARRXFP1KCNH2BRD4DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010131022-A1 | [1,2,4] TRIAZOLO [4,3-B] PYRIDAZINES AS LIGANDS OF THE ANDROGEN RECEPTOR | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | WO | disclosed |