Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 8/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.58 |
| ▸ | BRD4 | O60885 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3473971 | 1.00 | AR (0.75) | ARKCNH2BRD4HTTTDP1 | |
| SCHEMBL748810 | 1.00 | AR (0.75) | ARKCNH2BRD4HTTTDP1 | |
| SCHEMBL3475748 | 0.97 | AR (0.71) | ARKCNH2BRD4HTTTDP1 | |
| SCHEMBL748953 | 0.97 | AR (0.71) | ARKCNH2BRD4HTTTDP1 | |
| SCHEMBL13030810 | 0.97 | AR (0.71) | ARKCNH2BRD4HTTTDP1 | |
| SCHEMBL13065411 | 0.88 | AR (0.59) | ARKCNH2BRD4RXFP1DPP4 | |
| SCHEMBL13065413 | 0.88 | AR (0.59) | ARKCNH2BRD4RXFP1DPP4 | |
| SCHEMBL752809 | 0.86 | AR (1.00) | ARKCNH2BRD4HTTTDP1 | |
| SCHEMBL750071 | 0.84 | AR (0.73) | ARKCNH2BRD4HTTTDP1 | |
| SCHEMBL2263138 | 0.81 | AR (0.70) | ARKCNH2BRD4HTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292222-A1 | CHEMICAL COMPOUNDS 751 | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |
| US-20100292222-A1 | CHEMICAL COMPOUNDS 751 | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |
| US-20100292222-A1 | CHEMICAL COMPOUNDS 751 | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292222-A1 | CHEMICAL COMPOUNDS 751 | AR, NR5A1, KLK3 | AR 1/4885KCNH2 1951/4885BRD4 635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.