Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 18/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL390417 | 0.87 | GPR119 (0.54) | GPR119 | |
| SCHEMBL12674306 | 0.85 | GPR119 (0.49) | GPR119PIP4K2C | |
| SCHEMBL14016210 | 0.81 | GPR119 (0.43) | GPR119CYP2C9 | |
| SCHEMBL5140609 | 0.72 | GPR119 (0.37) | GPR119CHRM5 | |
| SCHEMBL388787 | 0.70 | GPR119 (0.63) | GPR119 | |
| SCHEMBL5140608 | 0.69 | GPR119 (0.36) | GPR119CHRM5 | |
| SCHEMBL388777 | 0.69 | GPR119 (0.55) | GPR119 | |
| SCHEMBL389263 | 0.67 | GPR119 (0.55) | GPR119 | |
| SCHEMBL385600 | 0.66 | GPR119 (0.58) | GPR119 | |
| SCHEMBL389272 | 0.66 | GPR119 (0.57) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838525-B2 | Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2010-11-23 | — | — | US | disclosed |