Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CBX7 | O95931 | 1/20 | 0.35 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.35 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.35 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL31693240 | 0.98 | SMN1; SMN2 (0.43) | SMN1; SMN2L3MBTL3L3MBTL1LMNAOPRL1 | |
| Hydrochloric Acid SCHEMBL31693414 | 0.98 | SMN1; SMN2 (0.43) | SMN1; SMN2L3MBTL3L3MBTL1LMNAOPRL1 | |
| SCHEMBL1306429 | 0.88 | SMN1; SMN2 (0.42) | SMN1; SMN2L3MBTL3L3MBTL1LMNAOPRL1 | |
| SCHEMBL3631668 | 0.88 | SMN1; SMN2 (0.42) | SMN1; SMN2L3MBTL3L3MBTL1LMNAOPRL1 | |
| SCHEMBL29336538 | 0.83 | HRH3 (0.41) | SMN1; SMN2CHRM2CHRM4CHRM1 | |
| SCHEMBL26091356 | 0.81 | SMN1; SMN2 (0.40) | SMN1; SMN2L3MBTL3L3MBTL1LMNAOPRL1 | |
| SCHEMBL27979100 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL3L3MBTL1LMNAOPRL1 | |
| SCHEMBL1306349 | 0.80 | MEN1 (0.44) | L3MBTL3L3MBTL1KDM4E | |
| SCHEMBL28452884 | 0.80 | L3MBTL3 (0.41) | L3MBTL3L3MBTL1KDM4E | |
| SCHEMBL19775351 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL3L3MBTL1OPRL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024035194-A1 | NOVEL HETEROARYL-SUBSTITUTED DERIVATIVE AND COMPOSITION FOR PREVENTING OR TREATING NEURODEGENERATIVE DISEASE, CANCER, AND INFLAMMATORY DISEASE COMPRISING SAME | 환인제약 주식회사 | 2024-02-15 | — | — | WO | claimed |
| WO-2023220396-A1 | METHODS OF TREATMENT USING A DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A (DYRK1A) INHIBITOR | FRESH TRACKS THERAPEUTICS, INC. (US) | 2023-11-16 | — | — | WO | claimed |
| CN-116916929-A | Novel use of pyrrolopyridine derivatives for the prevention or treatment of inflammatory diseases | 株式会社沃若诺伊 | 2023-10-20 | — | — | CN | claimed |
| EP-4259153-A1 | NOVEL USE OF PYRROLOPYRIDINE DERIVATIVES FOR PREVENTING OR TREATING INFLAMMATORY DISEASES | Voronoi Inc. (KR) | 2023-10-18 | — | — | EP | claimed |
| CN-115413278-A | Novel pyrimidine derivative and composition for preventing or treating neurodegenerative disease and cancer comprising same | 丸仁制药株式会社 | 2022-11-29 | — | — | CN | claimed |
| EP-3604304-B1 | PYRROLO-PYRIDINE DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF PROTEIN KINASE-RELATED DISEASES | DAEGU GYEONGBUK MEDICAL INNOVATION FOUND (KR) | 2022-09-07 | — | — | EP | claimed |
| WO-2022123311-A1 | NOVEL USE OF PYRROLOPYRIDINE DERIVATIVES FOR PREVENTING OR TREATING INFLAMMATORY DISEASES | VORONOI CO., LTD. (KR) | 2022-06-16 | — | — | WO | claimed |
| US-20220106307-A1 | PYRROLO-PYRIDINE DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF PROTEIN KINASE-RELATED DISEASES | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2022-04-07 | — | — | US | claimed |
| CN-113614086-A | Pyrrolopyrimidine derivative and pharmaceutical composition for preventing or treating protein kinase-associated diseases comprising the same as active ingredient | 沃若诺伊公司 | 2021-11-05 | — | — | CN | claimed |
| CN-113557237-A | Pyrrolopyridine derivatives and use thereof for preventing or treating protein kinase-associated diseases | 沃若诺伊公司 | 2021-10-26 | — | — | CN | claimed |
| WO-2020235973-A1 | NOVEL USE OF PYRROLO-PYRIDINE DERIVATIVE COMPOUND FOR PREVENTION AND/OR TREATMENT OF CANCER | 주식회사 보로노이 (KR) | 2020-11-26 | — | — | WO | claimed |
| WO-2020036437-A1 | SUBSTITUTED HETEROARYL DERIVATIVE, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASES WHICH CONTAINS SAME AS ACTIVE INGREDIENT | 재단법인 대구경북첨단의료산업진흥재단 | 2020-02-20 | — | — | WO | claimed |
| CN-110662745-A | Pyrrolopyridine derivatives, process for preparing the same, and pharmaceutical composition for preventing or treating protein kinase-associated diseases comprising the same as active ingredient | 大邱庆北尖端医疗产业振兴财团 | 2020-01-07 | — | — | CN | claimed |
| WO-2018174650-A9 | PYRROLO-PYRIDINE DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF PROTEIN KINASE-RELATED DISEASES | 재단법인 대구경북첨단의료산업진흥재단 | 2020-01-02 | — | — | WO | claimed |
| CN-106660955-B | Cyclohexene derivative, preparation method and the pharmaceutical composition for being used to prevent or treat metabolic disease comprising it as active constituent | 现代药品株式会社 | 2019-08-23 | — | — | CN | claimed |
| CN-106660955-A | Cyclohexene derivative, preparation method therefor, and pharmaceutical composition for preventing or treating metabolic diseases, containing same as active ingredient | 现代药品株式会社 | 2017-05-10 | — | — | CN | claimed |
| US-8053457-B2 | 3-imidazolyl-indoles for the treatment of proliferative diseases | NOVARTIS AG (CH) | 2011-11-08 | — | — | US | claimed |
| US-20100125064-A1 | 3-Imidazolyl-Indoles for the Treatment of Proliferative Diseases | NOVARTIS AG (CH) | 2010-05-20 | — | — | US | claimed |
| EP-2142535-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Novartis Ag (CH) | 2010-01-13 | — | — | EP | claimed |
| WO-2008119741-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2008-10-09 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100125064-A1 | 3-Imidazolyl-Indoles for the Treatment of Proliferative Diseases | MDM4, TP53, MDM2 | SMN1; SMN2 2884/4885L3MBTL3 279/4885L3MBTL1 796/4885 |
| US-20220106307-A1 | PYRROLO-PYRIDINE DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF PROTEIN KINASE-RELATED DISEASES | DYRK1A, DYRK2, DYRK1B | SMN1; SMN2 2702/4885L3MBTL3 4878/4885L3MBTL1 4864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.