Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 9/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ME2 | P23368 | 1/20 | 0.48 |
| ▸ | ME1 | P48163 | 1/20 | 0.48 |
| ▸ | ME3 | Q16798 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2873980 | 0.89 | CCR1 (0.64) | CCR1TP53MAPTPOLBALDH1A1 | |
| SCHEMBL2874558 | 0.87 | CCR1 (0.61) | CCR1TP53MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2873051 | 0.85 | CCR1 (0.77) | CCR1 | |
| SCHEMBL13682907 | 0.80 | CCR1 (0.64) | CCR1TP53MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2870322 | 0.80 | CCR1 (0.64) | CCR1TP53MAPTPOLBALDH1A1 | |
| SCHEMBL14039628 | 0.80 | CCR1 (0.64) | CCR1TP53MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2875360 | 0.79 | ME2 (0.55) | CCR1MAPTPOLBALDH1A1ME2 | |
| SCHEMBL14626295 | 0.79 | CCR1 (0.62) | CCR1TP53MAPTPOLBSMN1; SMN2 | |
| SCHEMBL2872952 | 0.78 | CCR1 (0.74) | CCR1TP53 | |
| SCHEMBL13024641 | 0.77 | CCR1 (0.60) | CCR1TP53MAPTPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842693-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2010-11-30 | — | — | US | disclosed |