Sugi Predict

Sugi Predict / Targets / ME2

ME2

NAD-dependent malic enzyme, mitochondrial · P23368 · ME2 on Sugi Atlas →

8,416 patent compounds predicted against ME2, 5,847 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL2310924 SCHEMBL2310924 0.58 8/20
SCHEMBL1128293 SCHEMBL1128293 0.55 7/20
SCHEMBL1977631 SCHEMBL1977631 0.52 6/20
SCHEMBL2312197 SCHEMBL2312197 0.51 6/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL2255585) 0.47 6/20
SCHEMBL2158309 SCHEMBL2158309 0.60 5/20
SCHEMBL2236040 SCHEMBL2236040 0.59 5/20
SCHEMBL2357897 SCHEMBL2357897 0.55 5/20
SCHEMBL2312297 SCHEMBL2312297 0.49 5/20
SCHEMBL1735467 SCHEMBL1735467 0.47 5/20
SCHEMBL1733516 SCHEMBL1733516 0.46 5/20
SCHEMBL2312088 SCHEMBL2312088 0.44 5/20
SCHEMBL2346745 SCHEMBL2346745 0.42 5/20
SCHEMBL2306481 SCHEMBL2306481 0.62 4/20
SCHEMBL1904981 SCHEMBL1904981 0.58 4/20
SCHEMBL2288557 SCHEMBL2288557 0.55 4/20
SCHEMBL1136936 SCHEMBL1136936 0.49 4/20
SCHEMBL2158310 SCHEMBL2158310 0.48 4/20
SCHEMBL110127 SCHEMBL110127 0.48 4/20
SCHEMBL2312607 SCHEMBL2312607 0.47 4/20

Clinical trials — most relevant to ME2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Mitochondrial Redox Modulation in Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Trial Comparing Imeglimin vs. Metformin Monotherapy PHASE4NOT_YET_RECRUITING
Glutamate for Metabolic Intervention in Coronary Surgery PHASE3COMPLETED
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome PHASE1/PHASE2COMPLETED
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy PHASE2ACTIVE_NOT_RECRUITING
Clinical Trial of 2-HOBA in Pulmonary Arterial Hypertension PHASE2NOT_YET_RECRUITING
Sirtuin-NAD Activator in Alzheimer's Disease PHASE1/PHASE2ACTIVE_NOT_RECRUITING
NADream: Effects of Nicotinamide Adenine Dinucleotide Supplementation on Sleep Quality in Healthy Individuals PHASE2RECRUITING
Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease PHASE2COMPLETED
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients PHASE2COMPLETED
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults PHASE1RECRUITING
Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia EARLY_PHASE1ACTIVE_NOT_RECRUITING
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside nanUNKNOWN
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP) nanNOT_YET_RECRUITING
GDF-15 as a Biomarker for Mitochondrial Disease nanCOMPLETED
Multi-omics Study in Citrin Deficiency nanACTIVE_NOT_RECRUITING
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
McArdle Disease Treatment by Ketogenic Diet nanCOMPLETED
Nutraceutical Composition Containing Natural Products Derivatives on the Modulation of the Endocrine Neuroimmune Axis nanCOMPLETED
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population nanUNKNOWN
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression nanCOMPLETED
Nephroprotective Effects of Carnitine and (PDE5) Inhibitor Agent Against Contrast Media-induced Nephropathy (CMN) nanUNKNOWN
Transcranial Photobiomodulation Therapy for the Treatment of Autistic Traits in Children and Adolescents With ADHD nanCOMPLETED
Evaluation of Transcranial Photobiomodulation in Autism Spectrum Disorder nanCOMPLETED
Genetic Diagnosis in Inborn Errors of Metabolism nanENROLLING_BY_INVITATION
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ME2 binder may also engage these)

ProteinNameSimilarity
Q99KE1 — 1.000 Q99KE1 →
P27443 — 1.000 P27443 →
P51615 — 1.000 P51615 →
P37223 — 0.997 P37223 →
P34105 — 0.996 P34105 →
P37225 — 0.994 P37225 →
P78715 — 0.994 P78715 →
Q9LYG3 — 0.993 Q9LYG3 →
B4ESY2 — 0.993 B4ESY2 →
Q7N6K4 — 0.993 Q7N6K4 →
Q6TU48 — 0.993 Q6TU48 →
Q9XGZ0 — 0.992 Q9XGZ0 →
Q086X9 — 0.992 Q086X9 →
Q8EAP2 — 0.992 Q8EAP2 →
P37222 — 0.992 P37222 →
A9MR05 — 0.992 A9MR05 →
Q57P88 — 0.992 Q57P88 →
B2VIF2 — 0.992 B2VIF2 →
P37224 — 0.991 P37224 →
A3QH80 — 0.991 A3QH80 →
B5F5W5 — 0.991 B5F5W5 →
Q54KB7 — 0.991 Q54KB7 →
Q1CGT4 — 0.991 Q1CGT4 →
C4ZWP8 — 0.991 C4ZWP8 →
A8GC31 — 0.991 A8GC31 →
B1KFN0 — 0.991 B1KFN0 →
B7L7H9 — 0.990 B7L7H9 →
B1IRX9 — 0.990 B1IRX9 →
P26616 — 0.990 P26616 →
B7MMW1 — 0.990 B7MMW1 →