Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | DRD3 | P35462 | 4/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | QPCT | Q16769 | 1/20 | 0.33 |
| ▸ | F12 | P00748 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2861506 | 0.99 | USP30 (0.38) | USP30FDPSDRD2DRD3HRH4 | |
| SCHEMBL2867705 | 0.74 | KDM4E (0.56) | USP30SLC6A2SLC6A4SLC6A3TSHR | |
| SCHEMBL2879234 | 0.73 | CNR2 (0.42) | FDPSDRD2DRD3CYP2A6DRD4 | |
| SCHEMBL2861663 | 0.72 | KDM4E (0.49) | USP30FDPSDRD2DRD3HRH4 | |
| SCHEMBL2867553 | 0.71 | SLC6A3 (0.48) | USP30FDPSDRD2DRD3HRH4 | |
| SCHEMBL28662752 | 0.70 | UTS2R (0.54) | USP30FDPSDRD2DRD3HRH4 | |
| SCHEMBL12933395 | 0.69 | CYP2A6 (0.46) | USP30FDPSDRD2DRD3HRH4 | |
| SCHEMBL2858169 | 0.68 | SLC6A4 (0.54) | USP30DRD2DRD3HRH4ADRA1A | |
| SCHEMBL13066976 | 0.68 | SLC6A4 (0.44) | USP30FDPSDRD2DRD3HRH4 | |
| SCHEMBL14491593 | 0.68 | SLC6A4 (0.44) | USP30FDPSDRD2DRD3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2253328-A1 | Cycloalkyl inhibitors of potassium channel function | Bristol-Myers Squibb Company (US) | 2010-11-24 | — | — | EP | disclosed |