Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIB | P23284 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MLYCD | O95822 | 1/20 | 0.35 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL102048 | 0.84 | FOLH1 (0.45) | MLYCDLMNAMAOAPOLQGAA | |
| SCHEMBL101719 | 0.83 | POLQ (0.48) | ALDH1A1CYP3A4TP53KMT2AMLYCD | |
| SCHEMBL3930452 | 0.80 | PPIB (0.44) | PPIBALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL13723886 | 0.80 | PPIB (0.44) | PPIBALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL3156597 | 0.78 | PHLPP2 (0.46) | PPIBALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL737988 | 0.75 | ALDH1A1 (0.47) | PPIBALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL4506617 | 0.75 | PPIB (0.47) | PPIBALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL3528672 | 0.75 | PHLPP2 (0.44) | PPIBALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL7110802 | 0.75 | FOLH1 (0.46) | PPIBALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL4738078 | 0.75 | PPIB (0.47) | PPIBALDH1A1CYP3A4MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129053-A2 | EGFR INHIBITORS AND METHODS OF TREATING DISORDERS | DANA FARBER CANCER INSTITUTE (US) | 2010-11-11 | — | — | WO | disclosed |