Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.30 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3372704 | 1.00 | CISD1 (0.36) | CISD1CSNK2A2CSNK2A1RPS6KB1AKT1 | |
| SCHEMBL3372738 | 1.00 | CISD1 (0.36) | CISD1CSNK2A2CSNK2A1RPS6KB1AKT1 | |
| SCHEMBL3373984 | 0.84 | CISD1 (0.40) | CISD1CSNK2A2CSNK2A1 | |
| SCHEMBL3373989 | 0.84 | CISD1 (0.40) | CISD1CSNK2A2CSNK2A1 | |
| SCHEMBL3372749 | 0.83 | CISD1 (0.33) | CISD1 | |
| SCHEMBL13069455 | 0.83 | CISD1 (0.33) | CISD1 | |
| SCHEMBL3375241 | 0.83 | CISD1 (0.33) | CISD1 | |
| SCHEMBL3373920 | 0.81 | CISD1 (0.37) | CISD1CSNK2A2CSNK2A1RPS6KB1AKT1 | |
| SCHEMBL14337695 | 0.81 | CISD1 (0.37) | CISD1CSNK2A2CSNK2A1RPS6KB1AKT1 | |
| SCHEMBL3373659 | 0.81 | CISD1 (0.37) | CISD1CSNK2A2CSNK2A1RPS6KB1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869036-B1 | SUBSTITUTED 1,5-NAPHTHYRIDINE AZOLIDINONES AS CDK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2010-11-03 | — | — | EP | disclosed |
| US-7304074-B2 | Substituted 1,5-naphthyridine azolinones | HOFFMANN-LA ROCHE INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304074-B2 | Substituted 1,5-naphthyridine azolinones | HOFFMANN-LA ROCHE INC. (US) | 2007-12-04 | — | — | US | disclosed |