Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 15/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | WNT1 | P04628 | 9/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2087530 | 0.85 | DYRK1A (0.57) | DYRK1AUSP30WNT1PAK1GSK3B | |
| SCHEMBL2088158 | 0.85 | DYRK1A (0.57) | DYRK1AUSP30WNT1PAK1GSK3B | |
| SCHEMBL2087526 | 0.85 | DYRK1A (0.57) | DYRK1AUSP30WNT1PAK1GSK3B | |
| SCHEMBL13069130 | 0.81 | USP30 (0.45) | DYRK1AUSP30WNT1PAK1GSK3B | |
| SCHEMBL13069617 | 0.80 | DYRK1A (0.43) | DYRK1AUSP30WNT1PAK1GSK3B | |
| SCHEMBL2086638 | 0.78 | DYRK1A (0.63) | DYRK1AWNT1GSK3B | |
| SCHEMBL2086641 | 0.78 | DYRK1A (0.63) | DYRK1AWNT1GSK3B | |
| SCHEMBL12514627 | 0.78 | USP30 (0.41) | DYRK1AUSP30WNT1GSK3BRIPK1 | |
| SCHEMBL492293 | 0.78 | CHRNA7 (0.63) | USP30 | |
| SCHEMBL2086696 | 0.78 | DYRK1A (0.67) | DYRK1AWNT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742944-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2010-11-10 | — | — | EP | disclosed |