Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 12/20 | 0.47 |
| ▸ | PPARG | P37231 | 9/20 | 0.47 |
| ▸ | PPARD | Q03181 | 5/20 | 0.42 |
| ▸ | FAAH | O00519 | 4/20 | 0.40 |
| ▸ | CDH1 | P12830 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | CPA1 | P15085 | 1/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378337 | 0.84 | PPARG (0.47) | PPARAPPARGCDH1CTNNB1TCF7L2 | |
| SCHEMBL10663764 | 0.78 | SMN1; SMN2 (0.45) | PPARAPPARGPPARD | |
| SCHEMBL3378784 | 0.76 | PPARA (0.47) | PPARAPPARGPPARD | |
| SCHEMBL10659695 | 0.75 | PPARG (0.46) | PPARAPPARG | |
| SCHEMBL10658226 | 0.73 | AR (0.53) | — | |
| SCHEMBL13069472 | 0.73 | PPARA (0.53) | PPARAPPARGPPARDCDH1CTNNB1 | |
| SCHEMBL3376160 | 0.73 | PPARG (0.52) | PPARAPPARGPPARD | |
| SCHEMBL10658222 | 0.72 | ESR1 (0.41) | PPARAPPARGPPARDCDH1CTNNB1 | |
| SCHEMBL10663175 | 0.72 | MAP4K4 (0.50) | PPARAPPARGPPARD | |
| SCHEMBL10660557 | 0.72 | ALDH2 (0.50) | PPARGEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1796665-B1 | COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | MERCK SHARP & DOHME (US) | 2010-11-17 | — | — | EP | disclosed |