Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1074788 | 0.90 | ACKR3 (0.56) | ACKR3TP53GAARXFP1TDP1 | |
| SCHEMBL13762949 | 0.84 | ACKR3 (0.50) | ACKR3TP53RXFP1TDP1MAPT | |
| SCHEMBL13762948 | 0.83 | MAPT (0.48) | ACKR3TP53RXFP1TDP1MAPT | |
| SCHEMBL13762953 | 0.83 | THRB (0.46) | ACKR3TP53GAARXFP1MAPT | |
| SCHEMBL1549596 | 0.83 | ACKR3 (0.62) | ACKR3TP53RXFP1MAPTCNR1 | |
| SCHEMBL13762954 | 0.82 | ACKR3 (0.54) | ACKR3TP53RXFP1MAPTCNR1 | |
| SCHEMBL13762956 | 0.82 | ACKR3 (0.54) | ACKR3TP53GAARXFP1MAPT | |
| SCHEMBL1074684 | 0.81 | ACKR3 (0.47) | ACKR3TP53RXFP1MAPTPOLB | |
| SCHEMBL3399997 | 0.81 | ACKR3 (0.47) | ACKR3TP53GAARXFP1MAPT | |
| SCHEMBL13068963 | 0.79 | ACKR3 (0.56) | ACKR3TP53GAAMAPTCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954274-B1 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX INC (US) | 2010-11-03 | — | — | EP | disclosed |