Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 19/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.53 |
| ▸ | HIPK2 | Q9H2X6 | 8/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 7/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.53 |
| ▸ | CLK2 | P49760 | 6/20 | 0.53 |
| ▸ | PRKACA | P17612 | 5/20 | 0.53 |
| ▸ | PAK4 | O96013 | 5/20 | 0.53 |
| ▸ | PRKX | P51817 | 5/20 | 0.53 |
| ▸ | MELK | Q14680 | 5/20 | 0.53 |
| ▸ | MAP4K5 | Q9Y4K4 | 5/20 | 0.53 |
| ▸ | PIM1 | P11309 | 5/20 | 0.53 |
| ▸ | JAK2 | O60674 | 4/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.53 |
| ▸ | CDK1 | P06493 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13923963 | 0.87 | CDC7 (0.63) | CDC7DYRK1AHIPK2DAPK3CDK5 | |
| SCHEMBL3376687 | 0.86 | CDC7 (0.65) | CDC7DYRK1AHIPK2DAPK3CDK5 | |
| SCHEMBL3374092 | 0.86 | CDC7 (0.65) | CDC7DYRK1AHIPK2DAPK3CDK5 | |
| Formic Acid SCHEMBL2086823 | 0.84 | CDC7 (0.62) | CDC7DYRK1AHIPK2DAPK3CDK5 | |
| SCHEMBL2085428 | 0.80 | CDC7 (0.56) | CDC7DYRK1AHIPK2DAPK3CDK5 | |
| SCHEMBL2085431 | 0.80 | CDC7 (0.56) | CDC7DYRK1AHIPK2DAPK3CDK5 | |
| SCHEMBL13069184 | 0.79 | DYRK1A (0.73) | DYRK1AGSK3B | |
| Formic Acid SCHEMBL2087409 | 0.78 | CDC7 (0.53) | CDC7DYRK1AHIPK2DAPK3CDK5 | |
| SCHEMBL13069595 | 0.77 | GSK3B (0.58) | DYRK1ACDK2GSK3B | |
| SCHEMBL4289886 | 0.76 | CDC7 (1.00) | CDC7DYRK1AHIPK2DAPK3CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742944-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2010-11-10 | — | — | EP | disclosed |