Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 17/20 | 0.53 |
| ▸ | STK17A | Q9UEE5 | 8/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.51 |
| ▸ | GSK3B | P49841 | 6/20 | 0.51 |
| ▸ | HIPK2 | Q9H2X6 | 10/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 9/20 | 0.49 |
| ▸ | CLK2 | P49760 | 9/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 9/20 | 0.49 |
| ▸ | PAK4 | O96013 | 8/20 | 0.49 |
| ▸ | PRKX | P51817 | 8/20 | 0.49 |
| ▸ | MELK | Q14680 | 8/20 | 0.49 |
| ▸ | MAP4K5 | Q9Y4K4 | 8/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 7/20 | 0.49 |
| ▸ | FLT3 | P36888 | 7/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.49 |
| ▸ | PRKACA | P17612 | 6/20 | 0.49 |
| ▸ | PIM1 | P11309 | 5/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2085428 | 0.97 | CDC7 (0.56) | CDC7STK17AAURKBDYRK1AGSK3B | |
| SCHEMBL2085431 | 0.97 | CDC7 (0.56) | CDC7STK17AAURKBDYRK1AGSK3B | |
| Formic Acid SCHEMBL2086823 | 0.94 | CDC7 (0.62) | CDC7STK17AAURKBDYRK1AGSK3B | |
| SCHEMBL3374092 | 0.91 | CDC7 (0.65) | CDC7STK17AAURKBDYRK1AGSK3B | |
| SCHEMBL3376687 | 0.91 | CDC7 (0.65) | CDC7STK17AAURKBDYRK1AGSK3B | |
| Formic Acid SCHEMBL3375290 | 0.90 | DYRK1A (0.53) | CDC7STK17AAURKBDYRK1AGSK3B | |
| SCHEMBL13923963 | 0.88 | CDC7 (0.63) | CDC7STK17AAURKBDYRK1AGSK3B | |
| SCHEMBL3374248 | 0.87 | DYRK1A (0.56) | CDC7STK17AAURKBDYRK1AGSK3B | |
| Formic Acid SCHEMBL2087311 | 0.84 | DYRK1A (0.53) | DYRK1AGSK3B | |
| SCHEMBL2088545 | 0.82 | DYRK1A (0.53) | CDC7DYRK1AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742944-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2010-11-10 | — | — | EP | claimed |
| US-20050250808-A1 | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICAL CORPORATION | 2005-11-10 | — | — | US | claimed |
| US-20110178075-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | XIE WENGE | 2011-07-21 | — | — | US | disclosed |
| US-7902217-B2 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICALS CORPORATION (US) | 2011-03-08 | — | — | US | disclosed |
| EP-1742944-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2010-11-10 | — | — | EP | disclosed |
| US-20090118232-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | XIE WENGE | 2009-05-07 | — | — | US | disclosed |
| US-7488737-B2 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICAL CORPORATION (US) | 2009-02-10 | — | — | US | disclosed |
| US-20050250808-A1 | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICAL CORPORATION | 2005-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178075-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | CHRNA7, CHRNA5, CHRNA2 | CDC7 1690/4885STK17A 885/4885AURKB 2407/4885 |
| US-20050250808-A1 | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof | CHRNA7, CHRNA5, CHRNA2 | CDC7 1690/4885STK17A 885/4885AURKB 2407/4885 |
| US-20090118232-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | CHRNA7, CHRNA5, CHRNA2 | CDC7 1690/4885STK17A 885/4885AURKB 2407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.