Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | PREP | P48147 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | UGCG | Q16739 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8231433 | 0.92 | F10 (0.48) | F10PARP1HDAC1PREPALDH1A1 | |
| SCHEMBL3382279 | 0.90 | F10 (0.49) | F10PARP1HDAC1PREPALDH1A1 | |
| SCHEMBL8231182 | 0.86 | F10 (0.43) | F10PARP1HDAC1PREPALDH1A1 | |
| SCHEMBL8230002 | 0.86 | F10 (0.41) | F10PARP1HDAC1ALDH1A1NR1I2 | |
| SCHEMBL3382382 | 0.82 | F10 (0.55) | F10PARP1HDAC1PREPALDH1A1 | |
| SCHEMBL5781798 | 0.82 | F10 (0.49) | F10PARP1HDAC1PREPALDH1A1 | |
| SCHEMBL8231854 | 0.80 | HDAC1 (0.39) | F10HDAC1ALDH1A1HDAC7MAPK1 | |
| SCHEMBL8228040 | 0.78 | F10 (0.45) | F10PARP1PREPALDH1A1MAPK1 | |
| SCHEMBL3377544 | 0.78 | F10 (0.51) | F10PARP1HDAC1PREPALDH1A1 | |
| SCHEMBL5782990 | 0.77 | F10 (0.55) | F10PARP1HDAC1PREPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029586-B1 | ISOINDOLIN-1-ONE-, ISOINDOLIN-3-ONE- AND ISOINDOLIN-1,3-DIONE-DERIVATIVES AND USE THEREOF | BAYER SCHERING PHARMA AG (DE) | 2010-11-24 | — | — | EP | disclosed |