Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 3/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | LSS | P48449 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3376896 | 0.88 | PPARD (0.53) | PPARGPPARDPPARA | |
| SCHEMBL3374136 | 0.82 | PPARG (0.49) | RAB9APPARGPPARDPPARANPC1 | |
| SCHEMBL3376824 | 0.81 | PPARG (0.42) | RAB9AEPHX2PPARGPPARDPPARA | |
| SCHEMBL3376815 | 0.80 | PPARA (0.53) | PPARGPPARDPPARA | |
| SCHEMBL3376160 | 0.80 | PPARG (0.52) | RAB9APPARGPPARDPPARANPC1 | |
| SCHEMBL3375295 | 0.79 | PPARA (0.47) | EPHX2PPARGPPARDPPARA | |
| SCHEMBL3377036 | 0.79 | PPARG (0.47) | PPARGPPARDPPARAMEN1KMT2A | |
| SCHEMBL13069647 | 0.77 | PPARG (0.46) | PPARGPPARDPPARAMEN1KMT2A | |
| SCHEMBL3378784 | 0.75 | PPARA (0.47) | PPARGPPARDPPARAMEN1KMT2A | |
| SCHEMBL3410208 | 0.74 | PPARA (0.48) | PPARGPPARDPPARANR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1796665-B1 | COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | MERCK SHARP & DOHME (US) | 2010-11-17 | — | — | EP | disclosed |