Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | RAD52 | P43351 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10169452 | 0.84 | NPC1 (0.67) | NPC1KDM4EALDH1A1THRBMEN1 | |
| SCHEMBL13070620 | 0.84 | KDM4E (0.69) | NPC1KDM4EALDH1A1THRBMEN1 | |
| SCHEMBL13167589 | 0.81 | NPC1 (0.67) | NPC1KDM4EALDH1A1THRBMEN1 | |
| SCHEMBL13071090 | 0.81 | NPC1 (0.67) | NPC1KDM4EALDH1A1THRBMEN1 | |
| SCHEMBL10210776 | 0.81 | NPC1 (0.74) | NPC1KDM4EALDH1A1THRBMEN1 | |
| SCHEMBL14537720 | 0.79 | TSHR (0.75) | NPC1KDM4EALDH1A1THRBMEN1 | |
| SCHEMBL13070618 | 0.79 | NPC1 (0.72) | NPC1KDM4EALDH1A1THRBMEN1 | |
| SCHEMBL13071094 | 0.78 | NPC1 (0.70) | NPC1KDM4EALDH1A1THRBMEN1 | |
| SCHEMBL13070701 | 0.77 | ALDH1A1 (0.60) | NPC1KDM4EALDH1A1THRBMEN1 | |
| SCHEMBL13071093 | 0.77 | KDM4E (0.77) | KDM4EALDH1A1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010131717-A1 | PRION PROTEIN STRUCTURE TRANSFORMATION INHIBITOR AND UTILIZATION OF SAME | 国立大学法人岐阜大学 (JP) | 2010-11-18 | — | — | WO | disclosed |