Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.48 |
| ▸ | CTSD | P07339 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.47 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.46 |
| ▸ | FNTB | P49356 | 1/20 | 0.46 |
| ▸ | GLS | O94925 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 3/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3163538 | 0.82 | GPR119 (0.50) | BACE1CTSDGPR119ACKR3FNTA | |
| SCHEMBL34473889 | 0.81 | MEN1 (0.52) | BACE1CTSDACKR3GLSCYP2C9 | |
| SCHEMBL1401229 | 0.81 | MEN1 (0.52) | BACE1CTSDACKR3GLSCYP2C9 | |
| SCHEMBL20520884 | 0.81 | MEN1 (0.52) | BACE1CTSDACKR3GLSCYP2C9 | |
| SCHEMBL13162812 | 0.81 | SCN9A (0.52) | BACE1CTSDGRIN2BGPR119ACKR3 | |
| SCHEMBL13161919 | 0.81 | SCN9A (0.52) | BACE1CTSDGRIN2BGPR119ACKR3 | |
| SCHEMBL2082202 | 0.79 | FNTA (0.47) | BACE1CTSDGPR119ACKR3FNTA | |
| SCHEMBL27157927 | 0.79 | BACE1 (0.45) | BACE1CTSDACKR3CYP2C9KDM1A | |
| SCHEMBL7464833 | 0.77 | GPR119 (0.54) | GPR119MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL13326507 | 0.76 | GPR119 (0.54) | GPR119USP30ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251343-A1 | IMIDAZOTHIAZOLES AS P38-KINASE-INHIBITORS | ARQULE, INC. (US) | 2010-11-17 | — | — | EP | disclosed |