Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 2/20 | 0.70 |
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1309133 | 0.92 | P2RX3 (0.59) | P2RX3USP30HTR6HDAC6HDAC4 | |
| SCHEMBL1308027 | 0.92 | P2RX3 (0.61) | P2RX3USP30HTR6KDM4EPKM | |
| SCHEMBL1308028 | 0.92 | P2RX3 (0.61) | P2RX3USP30HTR6KDM4EPKM | |
| SCHEMBL1308026 | 0.92 | P2RX3 (0.61) | P2RX3USP30HTR6KDM4EPKM | |
| SCHEMBL2888069 | 0.89 | P2RX3 (0.79) | P2RX3HDAC6HDAC1HDAC4KDM4E | |
| SCHEMBL2888065 | 0.89 | P2RX3 (0.79) | P2RX3HDAC6HDAC1HDAC4KDM4E | |
| SCHEMBL2888072 | 0.89 | P2RX3 (0.79) | P2RX3HDAC6HDAC1HDAC4KDM4E | |
| SCHEMBL1306813 | 0.87 | P2RX3 (0.75) | P2RX3USP30HTR6HDAC6HDAC4 | |
| SCHEMBL1306631 | 0.86 | P2RX3 (0.71) | P2RX3HDAC6HDAC1HDAC4KDM4E | |
| SCHEMBL1306637 | 0.86 | P2RX3 (0.71) | P2RX3HDAC6HDAC1HDAC4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |