P2RX3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL310444	1.00	19/20
SCHEMBL310823	1.00	19/20
SCHEMBL310997	1.00	19/20
SCHEMBL311221	1.00	19/20
SCHEMBL311216	1.00	18/20
SCHEMBL311816	1.00	18/20
SCHEMBL312096	1.00	18/20
SCHEMBL310920	0.77	18/20
SCHEMBL357080	0.61	18/20
SCHEMBL357564	0.61	18/20
SCHEMBL357731	0.51	18/20
SCHEMBL358473	0.51	18/20
SCHEMBL310360	1.00	17/20
SCHEMBL311122	1.00	17/20
SCHEMBL312462	1.00	17/20
SCHEMBL357414	0.61	17/20
SCHEMBL357412	0.59	17/20
SCHEMBL358483	0.57	17/20
SCHEMBL358789	0.57	17/20
SCHEMBL358868	0.51	17/20

Clinical trials — most relevant to P2RX3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Methylnaltrexone on the PK/PD Profiles of Ticagrelor in Patients Treated With Morphine	PHASE4	COMPLETED
H2 Haplotype and CYP3As Polymorphisms and the Antiplatelet Response to Clopidogrel	PHASE4	COMPLETED
Ticagrelor And PrEconditioning in Patients With coronaRy Artery diSease	PHASE2/PHASE3	COMPLETED
Botulinum Toxin Injections for Oral Neuropathic Pain	PHASE3	COMPLETED
Cefaliv® Compared to Neosaldina® in the Treatment of Migraine Attacks	PHASE3	WITHDRAWN
Effect of Botulinum Toxin A on Detrusor Overactivity and Renal Function in Chronic Spinal Cord Injured Patients	PHASE2	COMPLETED
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
Psychopharmacology for Cocaine Dependence - Buspirone	PHASE2	COMPLETED
Modulation of Central Hypersensitivity in Chronic Musculoskeletal Pain by Intravenous Tropisetron	PHASE2	COMPLETED
A Multiple-Dose Escalation Study to Evaluate the Safety, Tolerability and Pharmacokinetic of HS-10383	PHASE1	UNKNOWN
First Time in Human Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and the Effect of Food of Single Assending Doses of GSK1482160.	PHASE1	COMPLETED
Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults	EARLY_PHASE1	COMPLETED
Neuroinflammatory Interactions of ATP and P2X3 Receptor in the Airways of Chronic Cough Patients	nan	RECRUITING
Functional Magnetic Resonance Imaging of ATP Cough in Chronic Cough Patients	nan	COMPLETED
Caffeine vs. ALA in BMS Treatment. (BMS: Burning Mouth Syndrome. ALA: Alpha-Lipoic Acid.)	nan	COMPLETED
The Real-world Treatment Satisfaction by Gefapixiant in RCC	nan	RECRUITING
An Investigation Into the Mechanism of Inhalation Cough Challenge	nan	COMPLETED
ATP and P2X3 Receptor in Chronic Cough	nan	UNKNOWN
A P2X7R Single Nucleotide Mutation Promotes Chronic Allograft Vasculopathy	nan	COMPLETED
Effect of Botulinum Toxin A on Neurogenic Detrusor Overactivity in Chronic Spinal Cord Injured Patients	nan	COMPLETED
Neurogenic Mechanisms in Burning Mouth Syndrome	nan	COMPLETED
Local Injection of Botulinium Toxin-A in Children With Dysfunctional Voiding or Refractory Nocturnal Eneuresis	nan	RECRUITING
Visceral Afferents	nan	WITHDRAWN
Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy	nan	ENROLLING_BY_INVITATION
The Role of Urinary ATP in the Diagnosis, Treatment, and Follow-up of Children With Overactive Bladder	nan	COMPLETED
In Vitro Studies on Pharmacological Regulation and Genetic Risk Factors of Peripheral Human Nociceptors	nan	COMPLETED
P2X7 Receptor, Inflammation and Neurodegenerative Diseases	nan	COMPLETED
Suppressive Functions of Regulatory T Cells in Migraine	nan	NOT_YET_RECRUITING
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.	nan	UNKNOWN
Genotyping GUided Antiplatelet theRapy in pAtieNts Treated With Drug Eluting stEnts (GUARANTEE)	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a P2RX3 binder may also engage these)

Protein	Name	Similarity
Q3UR32	—	1.000	Q3UR32 →
P49654	—	1.000	P49654 →
Q91VE2	—	1.000	Q91VE2 →
P51578	—	0.999	P51578 →
O54803	—	0.995	O54803 →
Q5E9U1	—	0.994	Q5E9U1 →
Q63377	—	0.994	Q63377 →
Q202B1	—	0.992	Q202B1 →
Q93235	—	0.991	Q93235 →
P51579	—	0.991	P51579 →
P2RX5	P2X purinoceptor 5	0.991	landscape →
A8X4W9	—	0.991	A8X4W9 →
P25169	—	0.990	P25169 →
Q9BDK6	—	0.990	Q9BDK6 →
Q9XUY5	—	0.990	Q9XUY5 →
P97370	—	0.990	P97370 →
P51577	—	0.990	P51577 →
F8W463	—	0.989	F8W463 →
Q60489	—	0.989	Q60489 →
Q553Y0	—	0.989	Q553Y0 →
Q9JJX6	—	0.989	Q9JJX6 →
Q99ME6	—	0.989	Q99ME6 →
Q8BH24	—	0.988	Q8BH24 →
Q04651	—	0.988	Q04651 →
P30716	—	0.988	P30716 →
Q553Y1	—	0.988	Q553Y1 →
P18597	—	0.987	P18597 →
P25656	—	0.987	P25656 →
Q64663	—	0.987	Q64663 →
A5D7E2	—	0.986	A5D7E2 →