Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9928395 | 1.00 | HCRTR2 (0.33) | HCRTR2LIPEABCB1ALDH1A1LMNA | |
| SCHEMBL9900151 | 0.85 | KDM4E (0.33) | LIPEALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL10027157 | 0.83 | ATM (0.35) | ABCB1SMN1; SMN2MMP2ANPEPATM | |
| SCHEMBL14085831 | 0.83 | ATM (0.35) | ABCB1SMN1; SMN2MMP2ANPEPATM | |
| SCHEMBL9918107 | 0.83 | POLB (0.41) | HCRTR2LIPEABCB1ALDH1A1LMNA | |
| SCHEMBL14885072 | 0.83 | MAPT (0.33) | HCRTR2LIPEABCB1ALDH1A1LMNA | |
| SCHEMBL8007592 | 0.77 | NR1H2 (0.40) | ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6627764 | 0.74 | LIPE (0.43) | HCRTR2LIPEALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL2341978 | 0.73 | POLB (0.47) | — | |
| SCHEMBL13003862 | 0.73 | POLB (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132599-A1 | COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-11-18 | — | — | WO | disclosed |