LIPE — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL348448	1.00	20/20
SCHEMBL348777	1.00	20/20
SCHEMBL349602	1.00	20/20
SCHEMBL349793	1.00	20/20
SCHEMBL350088	1.00	20/20
SCHEMBL350214	1.00	20/20
SCHEMBL350689	1.00	20/20
SCHEMBL5543	0.88	20/20
SCHEMBL5544	0.88	20/20
SCHEMBL5932	0.83	20/20
SCHEMBL5933	0.83	20/20
SCHEMBL11241	0.82	20/20
SCHEMBL11242	0.82	20/20
SCHEMBL336298	0.79	20/20
SCHEMBL5347	0.77	20/20
SCHEMBL5351	0.76	20/20
SCHEMBL5352	0.76	20/20
SCHEMBL10129	0.74	20/20
SCHEMBL10130	0.74	20/20
SCHEMBL10681	0.74	20/20

Clinical trials — most relevant to LIPE by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect Of Exenatide Treatment on Liver Fat Content in Patients With Diabetes	PHASE4	COMPLETED
The Effect of Liraglutide on Dietary Lipid Induced Insulin Resistance in Humans	PHASE4	COMPLETED
Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency	PHASE3	COMPLETED
Short-term Effects of Leptin in People With Lipodystrophy	PHASE2	COMPLETED
Orlistat for the Treatment of Type I Hyperlipoproteinemia	PHASE2	COMPLETED
Insulin Regulation of Lipolysis and Lipolysis Proteins	EARLY_PHASE1	RECRUITING
Acute Pancreatitis Targets (APT) Study	nan	COMPLETED
Effect of Cryolipolysis on Insulin Resistance	nan	UNKNOWN
Fat Tissue Microperfusion to Measure Leptin Secretion and Its Relations With Fat Breakdown in Humans	nan	COMPLETED
Effect of Molecular Hydrogen in Patients With NAFLD	nan	COMPLETED
Effect of Saturated Fat on Large Low-density Lipoprotein (LDL) and High-density Lipoprotein (HDL)	nan	COMPLETED
Effect of SGLT2 Inhibitors on NAFLD in Type 2 Diabetic Patients with Diabetic Nephropathy	nan	NOT_YET_RECRUITING
Metabolic Signalling in Muscle- and Adipose-tissue Following Insulin Withdrawal and Growth Hormone Injection.	nan	COMPLETED
Study to Re-assess and Re-confirm Data Previously Recorded About the Incidence and Severity of Acute Abdominal Pancreatitis Episodes in Lipoprotein Lipase Deficient (LPLD) Subjects Previously Enrolled on AMT Clinical Studies	nan	UNKNOWN
Triglyceride-rich LIPoproteins and INflammatory Cytokines After Oral FAT Loading as Potential Early Biomarkers of the Risk of Progression Towards DIABETES and Development of Complications. LIPINFAT Diabetes Study.	nan	RECRUITING
Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis	nan	RECRUITING
Dietary Modulation of Hepatic Lipase (LIPC) -514 C/T Variant Associations With Lipids and Glucose	nan	COMPLETED
Effectiveness of Nutritional Program Among Diabetic Patients	nan	UNKNOWN
Hypertriglyceridemia-associated Acute Pancreatitis: Apheresis Vs. Conservative Treatment	nan	COMPLETED
Body Composition and Very-Low-Density-Lipoprotein-Triglycerides (VLDL-TG) Kinetics	nan	COMPLETED
Production of Free Fatty Acids From Blood Triglycerides	nan	COMPLETED
Effects of Growth Hormone Administration on Cardiovascular Risk in Cured Acromegalics With Growth Hormone Deficiency	nan	COMPLETED
Effects of Capacitive Radiofrequency at the Dermis and Adipose Tissue	nan	COMPLETED
Metabolic Heterogeneity Underlying Hypertriglyceridemia: Hepatic Triglyceride Biosynthesis in Humans With Different Insulin Resistance Phenotypes	nan	RECRUITING
De Novo Lipogenesis and Insulin Sensitivity in Obese	nan	COMPLETED
The Fasting Study - Unraveling the Mechanistic Effects of Prolonged Fasting in Humans.	nan	COMPLETED
Effects of Lipids on Gastric Emptying, Satiety Hormones, and Appetite in Severe Overweight	nan	COMPLETED
Study Comparing Blood Levels of Fatty Acids After Consuming Two Forms of Cod Liver Oil	nan	COMPLETED
Circadian Rhythms in Human Adipose	nan	RECRUITING
An Analysis of Lipid and Glucose Metabolism Following Bariatric Surgery	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a LIPE binder may also engage these)

Protein	Name	Similarity
P15304	—	0.997	P15304 →
Q9BQK8	—	0.996	Q9BQK8 →
Q99PI5	—	0.993	Q99PI5 →
Q2PFD7	—	0.993	Q2PFD7 →
Q9R101	—	0.992	Q9R101 →
P54310	—	0.992	P54310 →
Q92539	—	0.992	Q92539 →
Q9UPV7	—	0.992	Q9UPV7 →
Q99PI4	—	0.991	Q99PI4 →
A2AHC3	—	0.991	A2AHC3 →
Q5BIR3	—	0.991	Q5BIR3 →
Q8TBC3	—	0.991	Q8TBC3 →
O95343	—	0.990	O95343 →
P59729	—	0.990	P59729 →
Q9P202	—	0.990	Q9P202 →
Q6DGF9	—	0.990	Q6DGF9 →
D3YWQ0	—	0.990	D3YWQ0 →
Q5TH69	—	0.990	Q5TH69 →
Q9H329	—	0.990	Q9H329 →
Q7TN99	—	0.990	Q7TN99 →
Q5TKR9	—	0.990	Q5TKR9 →
Q76LL6	—	0.990	Q76LL6 →
A3KMV1	—	0.990	A3KMV1 →
Q8CJE2	—	0.990	Q8CJE2 →
P35054	—	0.990	P35054 →
Q60700	—	0.990	Q60700 →
P56931	—	0.990	P56931 →
A2A3K4	—	0.990	A2A3K4 →
Q80UW3	—	0.990	Q80UW3 →
A6QP06	—	0.989	A6QP06 →