Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13037186 | 1.00 | MEN1 (0.59) | MEN1KMT2ALMNANAMPTHDAC8 | |
| SCHEMBL13073431 | 0.81 | KMT2A (0.85) | MEN1KMT2AHDAC8 | |
| SCHEMBL19972744 | 0.81 | KMT2A (0.85) | MEN1KMT2AHDAC8 | |
| SCHEMBL4649174 | 0.79 | TSHR (0.42) | MEN1KMT2ALMNANAMPTSMN1; SMN2 | |
| SCHEMBL21540683 | 0.77 | KDM4E (0.55) | MEN1KMT2ALMNAFAAHNPC1 | |
| SCHEMBL2601969 | 0.77 | NAMPT (0.53) | LMNANAMPTFAAHNPC1RAB9A | |
| SCHEMBL4649677 | 0.77 | SIGMAR1 (0.46) | LMNAFAAHTSHRALDH1A1 | |
| SCHEMBL5195093 | 0.76 | SMN1; SMN2 (0.49) | MEN1KMT2ALMNAHDAC8FAAH | |
| SCHEMBL3378134 | 0.76 | TSHR (0.65) | MEN1KMT2ALMNAFAAHNPC1 | |
| SCHEMBL29407510 | 0.76 | TSHR (0.65) | MEN1KMT2ALMNAFAAHNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825256-B2 | Inducible nitric oxide synthase dimerization inhibitors | KALYPSYS, INC. (US) | 2010-11-02 | — | — | US | disclosed |