Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | PRKX | P51817 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | F2RL3 | Q96RI0 | 4/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12566976 | 0.65 | PIK3CG (0.41) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL452503 | 0.61 | F2RL3 (0.42) | TP53F2RL3EGFR | |
| SCHEMBL31167832 | 0.61 | SMN1; SMN2 (0.44) | TP53MEN1KMT2ANPC1RAB9A | |
| SCHEMBL13075446 | 0.60 | CHEK1 (0.61) | NPC1RAB9ASMN1; SMN2MAPTCLK4 | |
| SCHEMBL16296223 | 0.59 | MAP4K4 (0.37) | CLK4MAP4K4PAK4CSF1RRET | |
| SCHEMBL2251355 | 0.57 | ALDH1A1 (0.35) | SMN1; SMN2HSD17B10 | |
| SCHEMBL16439356 | 0.57 | PIK3CG (0.34) | — | |
| SCHEMBL31489851 | 0.57 | PIK3CD (0.33) | — | |
| SCHEMBL16439317 | 0.57 | PIK3CG (0.46) | NPC1RAB9AMAPT | |
| SCHEMBL16439310 | 0.57 | PDE10A (0.41) | HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010133534-A1 | BICYCLIC AMINO SUBSTITUTED COMPOUNDS AS PI3K INHIBITORS | CELLZOME LIMITED (GB) | 2010-11-25 | — | — | WO | disclosed |