Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 9/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL116514 | 0.89 | POLB (0.41) | POLBGPBAR1PTGS2PDE2APDE7A | |
| SCHEMBL10284733 | 0.88 | PTGS2 (0.42) | POLBPTGS2ALDH1A1PDE2APDE7A | |
| SCHEMBL10284408 | 0.88 | POLB (0.41) | POLBMAPTGPBAR1PTGS2LMNA | |
| SCHEMBL355701 | 0.87 | POLB (0.45) | POLBPTGS2PDE2APDE7APDE10A | |
| SCHEMBL10249035 | 0.86 | BRD4 (0.36) | POLBSMN1; SMN2PDE10A | |
| SCHEMBL10284538 | 0.86 | POLB (0.40) | POLBGPBAR1PTGS2ALDH1A1LMNA | |
| SCHEMBL16380358 | 0.82 | POLB (0.44) | POLBGPBAR1TACR1ALDH1A1GAA | |
| SCHEMBL357857 | 0.81 | PDE10A (0.48) | POLBGPBAR1PTGS2SMN1; SMN2PDE2A | |
| SCHEMBL16612050 | 0.80 | POLB (0.45) | POLBPTGS2PDE10APTGS1CYP17A1 | |
| SCHEMBL116863 | 0.80 | POLB (0.43) | POLBGPBAR1SMN1; SMN2PDE2APDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424856-B1 | FUSED HETEROCYCLIC COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL CO (JP) | 2014-12-31 | — | — | EP | disclosed |
| WO-2010125985-A1 | FUSED HETEROCYCLIC COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-11-04 | — | — | WO | disclosed |