Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.41 |
| ▸ | PLK1 | P53350 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 6/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | ROS1 | P08922 | 1/20 | 0.34 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13076190 | 0.77 | CDK4 (0.51) | EGFRALKPLK1FGFR1BTK | |
| SCHEMBL23606812 | 0.72 | FGFR4 (0.49) | EGFRFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL13076192 | 0.69 | CDK4 (0.46) | EGFRALKPLK1 | |
| SCHEMBL30044654 | 0.65 | FYN (0.43) | EGFRALKSTAT3 | |
| SCHEMBL21596984 | 0.65 | FYN (0.43) | EGFRALKSTAT3 | |
| SCHEMBL310055 | 0.64 | SUV39H2 (0.45) | EGFRALKPLK1STAT3AURKA | |
| SCHEMBL29661369 | 0.64 | SUV39H2 (0.45) | EGFRALKPLK1STAT3AURKA | |
| SCHEMBL24603026 | 0.64 | SUV39H2 (0.45) | EGFRALKPLK1STAT3AURKA | |
| Hydrochloric Acid SCHEMBL29367159 | 0.63 | SUV39H2 (0.44) | EGFRALKPLK1STAT3AURKA | |
| SCHEMBL17059200 | 0.62 | EGFR (0.59) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125402-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2010-11-04 | — | — | WO | disclosed |