Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.46 |
| ▸ | CCND1 | P24385 | 4/20 | 0.46 |
| ▸ | CCND3 | P30281 | 4/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.46 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 6/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL111500 | 0.75 | CDK4 (0.77) | CDK4CDK6CCND1CCND3CCNA2 | |
| SCHEMBL13076543 | 0.72 | CDK4 (0.64) | CDK4CDK6CCND1CCND3CCNA2 | |
| SCHEMBL13075596 | 0.69 | EGFR (0.41) | EGFRALKPLK1 | |
| SCHEMBL23606812 | 0.68 | FGFR4 (0.49) | HDAC1EGFR | |
| SCHEMBL112881 | 0.66 | CDK4 (0.74) | CDK4CDK6CCND1CCND3CCNA2 | |
| SCHEMBL111463 | 0.66 | CDK4 (0.75) | CDK4CDK6CCND1CCND3CCNA2 | |
| SCHEMBL2142406 | 0.66 | CDK4 (0.78) | CDK4CDK6CCND1CCND3CCNA2 | |
| SCHEMBL2143680 | 0.66 | CDK4 (0.65) | CDK4CDK6CCND1CCND3CCNA2 | |
| SCHEMBL111803 | 0.65 | CDK4 (0.80) | CDK4CDK6CCND1CCND3CCNA2 | |
| SCHEMBL31060547 | 0.65 | CDK4 (0.80) | CDK4CDK6CCND1CCND3CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125402-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2010-11-04 | — | — | WO | disclosed |