Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 20/20 | 0.65 |
| ▸ | TRPV4 | Q9HBA0 | 11/20 | 0.65 |
| ▸ | TRPV3 | Q8NET8 | 4/20 | 0.65 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14305979 | 0.85 | TRPA1 (0.75) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL14479317 | 0.85 | TRPA1 (0.76) | TRPA1TRPV4TRPV3 | |
| SCHEMBL13175033 | 0.83 | TRPA1 (0.75) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL3794851 | 0.81 | TRPA1 (0.80) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL13076702 | 0.80 | TRPA1 (0.66) | TRPA1TRPV4TRPV3 | |
| SCHEMBL3805988 | 0.79 | TRPA1 (0.78) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL1689589 | 0.79 | TRPA1 (1.00) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL12291295 | 0.77 | TRPA1 (0.66) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL13075861 | 0.77 | TRPA1 (0.65) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL30167897 | 0.77 | TRPA1 (1.00) | TRPA1TRPV4TRPV3TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125469-A1 | PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-11-04 | — | — | WO | disclosed |