Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | BCL9 | O00512 | 5/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.32 |
| ▸ | PAICS | P22234 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 3/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL112968 | 0.81 | CDK4 (0.52) | CDK4CCND1CCND3CDK6TBK1 | |
| SCHEMBL13075895 | 0.78 | CDK4 (0.64) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL110672 | 0.71 | CDK4 (0.55) | CDK4CCND1CCND3CDK6TBK1 | |
| SCHEMBL111358 | 0.67 | CDK4 (0.51) | CDK4CCND1CCND3CDK6JAK1 | |
| SCHEMBL111791 | 0.67 | CDK4 (0.48) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL13076282 | 0.66 | CDK4 (0.43) | CDK4CCND1CCND3CDK6JAK3 | |
| SCHEMBL111484 | 0.64 | CDK4 (0.62) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL112413 | 0.61 | CDK4 (0.53) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL111573 | 0.61 | CDK4 (0.80) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL111458 | 0.61 | CDK4 (0.58) | CDK4CCND1CCND3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125402-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2010-11-04 | — | — | WO | disclosed |