Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CCND1 | P24385 | 2/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.34 |
| ▸ | ALB | P02768 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 3/20 | 0.33 |
| ▸ | INSR | P06213 | 3/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.33 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | PIR | O00625 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL111269 | 0.90 | CDK4 (0.49) | CDK4CCND1CCND3CDK6MCL1 | |
| SCHEMBL13076282 | 0.85 | CDK4 (0.43) | CDK4CCND1CCND3CDK6GSK3B | |
| SCHEMBL110672 | 0.74 | CDK4 (0.55) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL13075594 | 0.73 | CDK4 (0.43) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL2143455 | 0.69 | CDK4 (0.51) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL111458 | 0.69 | CDK4 (0.58) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL112968 | 0.69 | CDK4 (0.52) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL112506 | 0.68 | CDK4 (0.63) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL108753 | 0.68 | CDK4 (0.57) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL112413 | 0.68 | CDK4 (0.53) | CDK4CCND1CCND3CDK6CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125402-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2010-11-04 | — | — | WO | disclosed |