Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 18/20 | 0.68 |
| ▸ | TRPV4 | Q9HBA0 | 9/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13076325 | 0.91 | TRPA1 (0.69) | TRPA1TRPV4TRPV3 | |
| SCHEMBL13076324 | 0.87 | TRPA1 (0.70) | TRPA1TRPV4TRPV3 | |
| SCHEMBL3810127 | 0.86 | TRPA1 (0.76) | TRPA1TRPV4MAPTMEN1ALDH1A1 | |
| SCHEMBL13076877 | 0.85 | TRPA1 (0.69) | TRPA1TRPV4TRPV3 | |
| SCHEMBL13075960 | 0.83 | TRPA1 (0.69) | TRPA1TRPV4TRPV3 | |
| SCHEMBL13076673 | 0.83 | TRPA1 (0.77) | TRPA1TRPV4TRPV3 | |
| SCHEMBL13075962 | 0.83 | TRPA1 (0.65) | TRPA1TRPV4TRPV3 | |
| SCHEMBL13076331 | 0.81 | TRPA1 (0.67) | TRPA1TRPV4 | |
| SCHEMBL13076328 | 0.81 | TRPA1 (0.69) | TRPA1TRPV4 | |
| SCHEMBL1803340 | 0.81 | TRPA1 (1.00) | TRPA1TRPV4TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125469-A1 | PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-11-04 | — | — | WO | disclosed |