Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 20/20 | 0.74 |
| ▸ | TRPV4 | Q9HBA0 | 10/20 | 0.74 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13076688 | 0.94 | TRPA1 (0.74) | TRPA1TRPV4TRPV3 | |
| SCHEMBL3802142 | 0.88 | TRPA1 (0.78) | TRPA1TRPV4TRPV3 | |
| SCHEMBL3796445 | 0.88 | TRPA1 (0.81) | TRPA1TRPV4TRPV3 | |
| SCHEMBL13175079 | 0.86 | TRPA1 (0.78) | TRPA1TRPV4TRPV3 | |
| SCHEMBL13075869 | 0.85 | TRPA1 (0.73) | TRPA1TRPV4TRPV3 | |
| SCHEMBL1802300 | 0.85 | TRPA1 (1.00) | TRPA1TRPV4TRPV3 | |
| SCHEMBL13076687 | 0.85 | TRPA1 (0.74) | TRPA1TRPV4TRPV3 | |
| SCHEMBL1689571 | 0.84 | TRPA1 (1.00) | TRPA1TRPV4TRPV3 | |
| SCHEMBL9933398 | 0.83 | TRPA1 (0.79) | TRPA1TRPV4TRPV3 | |
| SCHEMBL612053 | 0.82 | TRPA1 (1.00) | TRPA1TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125469-A1 | PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-11-04 | — | — | WO | disclosed |