SCHEMBL13076543

SCHEMBL13076543

CN(C)C1CCN(c2ccc3nc(C(=O)c4ccc(N)c(-c5cncc6ccccc56)c4)[nH]c3n2)CC1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 6/20 0.64
CCND1 P24385 6/20 0.64
CCND3 P30281 5/20 0.64
CDK6 Q00534 5/20 0.64
CCNA2 P20248 3/20 0.64
CDK2 P24941 3/20 0.64
CCNA1 P78396 3/20 0.64
CDK1 P06493 3/20 0.64
CCNB1 P14635 3/20 0.64
PARP1 P09874 1/20 0.40
MMP9 P14780 2/20 0.36
HTR1A P08908 1/20 0.35
HTR7 P34969 1/20 0.35
CCNC P24863 1/20 0.34
CDK8 P49336 1/20 0.34
WNT1 P04628 2/20 0.34
DYRK1A Q13627 2/20 0.34
PDGFRB P09619 1/20 0.34
FGFR1 P11362 1/20 0.34
KDR P35968 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL111803 0.90 CDK4 (0.80) CDK4CCND1CCND3CDK6CCNA2
SCHEMBL31060547 0.90 CDK4 (0.80) CDK4CCND1CCND3CDK6CCNA2
SCHEMBL13076270 0.89 CDK4 (0.53) CDK4CCND1CCND3CDK6CCNA2
SCHEMBL13076292 0.87 CDK4 (0.48) CDK4CCND1CCND3CDK6CCNA2
SCHEMBL114117 0.86 CDK4 (0.78) CDK4CCND1CCND3CDK6CCNA2
SCHEMBL10268485 0.83 CDK4 (0.45) CDK4CCND1CCND3CDK6CCNA2
SCHEMBL13076269 0.80 CDK4 (0.45) CDK4CCND1CCND3CDK6CCNA2
SCHEMBL13076251 0.80 CDK4 (0.48) CDK4CCND1CCND3CDK6CCNA2
SCHEMBL13076544 0.79 CDK4 (0.41) CDK4CCND1CCND3CDK6CCNA2
SCHEMBL110134 0.79 CDK4 (0.66) CDK4CCND1CCND3CDK6CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010125402-A1 IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES NOVARTIS AG (CH) 2010-11-04 WO disclosed