SCHEMBL13076544

SCHEMBL13076544

Nc1ccc(C(=O)c2nc3ccc(N4CCC(O)CC4)nc3[nH]2)cc1-c1cncc2[nH]ccc12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 4/20 0.41
CCND1 P24385 4/20 0.41
CCND3 P30281 4/20 0.41
CDK6 Q00534 4/20 0.41
CCNA2 P20248 3/20 0.41
CDK2 P24941 3/20 0.41
CCNA1 P78396 3/20 0.41
CDK1 P06493 2/20 0.41
CCNB1 P14635 2/20 0.41
DYRK1A Q13627 4/20 0.36
CLK2 P49760 3/20 0.36
CLK3 P49761 3/20 0.36
ATR Q13535 7/20 0.36
PDE10A Q9Y233 1/20 0.34
CHEK1 O14757 2/20 0.34
PDCD1 Q15116 2/20 0.34
ATRIP Q8WXE1 2/20 0.34
CD274 Q9NZQ7 2/20 0.34
MTOR P42345 2/20 0.34
GSK3B P49841 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13076194 0.90 CDK4 (0.38) CDK4CCND1CCND3CDK6CCNA2
SCHEMBL112523 0.89 CDK4 (0.54) CDK4CCND1CCND3CDK6CCNA2
SCHEMBL111482 0.81 CDK4 (0.65) CDK4CCND1CCND3CDK6CCNA2
SCHEMBL13076193 0.81 CDK4 (0.37) CDK4CCND1CCND3CDK6CCNA2
SCHEMBL111608 0.80 CDK4 (0.49) CDK4CCND1CCND3CDK6CCNA2
SCHEMBL13076543 0.79 CDK4 (0.64) CDK4CCND1CCND3CDK6CCNA2
SCHEMBL13076257 0.79 CDK4 (0.60) CDK4CCND1CCND3CDK6CCNA2
SCHEMBL111671 0.79 CDK4 (0.48) CDK4CCND1CCND3CDK6CCNA2
SCHEMBL13076292 0.78 CDK4 (0.48) CDK4CCND1CCND3CDK6CCNA2
SCHEMBL113299 0.76 CDK4 (0.45) CDK4CCND1CCND3CDK6CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010125402-A1 IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES NOVARTIS AG (CH) 2010-11-04 WO disclosed