Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.44 |
| ▸ | CCND1 | P24385 | 4/20 | 0.44 |
| ▸ | CCND3 | P30281 | 4/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.44 |
| ▸ | CDK1 | P06493 | 3/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | FABP6 | P51161 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL111248 | 0.90 | CDK4 (0.52) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL3720082 | 0.74 | CDK4 (0.55) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL13076543 | 0.69 | CDK4 (0.64) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL13076292 | 0.67 | CDK4 (0.48) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL115091 | 0.67 | CDK4 (0.65) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL111500 | 0.66 | CDK4 (0.77) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL2142391 | 0.65 | CDK4 (0.64) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL175564 | 0.65 | CDK4 (0.60) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL13076260 | 0.65 | CYP17A1 (0.46) | MMP9KDM4EMAPTHSD17B10MMP1 | |
| SCHEMBL112881 | 0.65 | CDK4 (0.74) | CDK4CCND1CCND3CDK6CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125402-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2010-11-04 | — | — | WO | disclosed |