Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.66 |
| ▸ | MEN1 | O00255 | 5/20 | 0.66 |
| ▸ | TSHR | P16473 | 5/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.58 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.58 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3812270 | 0.86 | KDM4E (0.77) | MAP3K7KDM4EKMT2AMEN1TSHR | |
| SCHEMBL13076216 | 0.85 | ITK (0.51) | MAP3K7KDM4EKMT2AMEN1TSHR | |
| SCHEMBL13076210 | 0.85 | KDM4E (0.51) | MAP3K7KDM4EKMT2AMEN1TSHR | |
| SCHEMBL20063045 | 0.83 | MAP3K7 (0.83) | MAP3K7KDM4EKMT2AMEN1TSHR | |
| SCHEMBL29850001 | 0.81 | MAP3K7 (0.83) | MAP3K7KDM4EKMT2AMEN1TSHR | |
| SCHEMBL20063046 | 0.81 | MAP3K7 (1.00) | MAP3K7KDM4EKMT2AMEN1TSHR | |
| SCHEMBL29722841 | 0.81 | MAP3K7 (1.00) | MAP3K7KDM4EKMT2AMEN1TSHR | |
| SCHEMBL3798611 | 0.80 | MAP3K7 (0.82) | MAP3K7KDM4EKMT2AMEN1TSHR | |
| SCHEMBL3801292 | 0.79 | KDM4E (0.69) | MAP3K7KDM4EKMT2AMEN1TSHR | |
| Hydrochloric Acid SCHEMBL3791352 | 0.79 | MAP3K7 (0.80) | MAP3K7KDM4EKMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |