Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.78 |
| ▸ | MEN1 | O00255 | 5/20 | 0.78 |
| ▸ | TSHR | P16473 | 4/20 | 0.78 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.76 |
| ▸ | HTT | P42858 | 5/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | USP2 | O75604 | 2/20 | 0.69 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.69 |
| ▸ | PPARG | P37231 | 1/20 | 0.69 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.69 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.69 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.69 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26325256 | 0.91 | MAP3K7 (0.80) | MAP3K7KDM4EKMT2AMEN1TSHR | |
| SCHEMBL20063046 | 0.91 | MAP3K7 (1.00) | MAP3K7KDM4EKMT2AMEN1TSHR | |
| SCHEMBL29722841 | 0.91 | MAP3K7 (1.00) | MAP3K7KDM4EKMT2AMEN1TSHR | |
| SCHEMBL29850001 | 0.91 | MAP3K7 (0.83) | MAP3K7KDM4EKMT2AMEN1TSHR | |
| SCHEMBL3812270 | 0.88 | KDM4E (0.77) | MAP3K7KDM4EKMT2AMEN1TSHR | |
| SCHEMBL26325416 | 0.88 | MAP3K7 (0.86) | MAP3K7KDM4EKMT2AMEN1TSHR | |
| SCHEMBL3798611 | 0.88 | MAP3K7 (0.82) | MAP3K7KDM4EKMT2AMEN1TSHR | |
| Hydrochloric Acid SCHEMBL3791352 | 0.87 | MAP3K7 (0.80) | MAP3K7KDM4EKMT2AMEN1TSHR | |
| SCHEMBL29827291 | 0.84 | IRAK4 (0.89) | MAP3K7KDM4EKMT2AMEN1TSHR | |
| SCHEMBL25956620 | 0.84 | IRAK4 (0.89) | MAP3K7KDM4EKMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11767298-B2 | Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase | DUKE UNIVERSITY (US) | 2023-09-26 | — | — | US | disclosed |
| US-20180105500-A1 | NOVEL INHIBITORS OF TRANSFORMING GROWTH FACTOR KINASE AND METHODS OF USE THEREOF | DUKE UNIVERSITY | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105500-A1 | NOVEL INHIBITORS OF TRANSFORMING GROWTH FACTOR KINASE AND METHODS OF USE THEREOF | TAB1, BMP2K, SMAD3 | MAP3K7 14/4885KDM4E 1526/4885KMT2A 2322/4885 |
| US-11767298-B2 | Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase | TAB1, CHUK, TGFBR1 | MAP3K7 19/4885KDM4E 915/4885KMT2A 1829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.