Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 7/20 | 0.56 |
| ▸ | THRB | P10828 | 7/20 | 0.56 |
| ▸ | RARB | P10826 | 2/20 | 0.53 |
| ▸ | PLK1 | P53350 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | PLA2G1B | P04054 | 3/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 3/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18175226 | 0.81 | SMN1; SMN2 (0.55) | PLK1KMT2AALDH1A1HPGD | |
| SCHEMBL607614 | 0.79 | RARB (0.62) | THRATHRBRARBPLK1MEN1 | |
| SCHEMBL10886969 | 0.79 | RARB (0.62) | THRATHRBRARBPLK1MEN1 | |
| SCHEMBL3374775 | 0.77 | RARB (0.55) | THRATHRBRARBPLK1MEN1 | |
| SCHEMBL28017840 | 0.76 | RARB (0.59) | THRATHRBRARBPLK1MEN1 | |
| SCHEMBL6889098 | 0.76 | SMN1; SMN2 (0.64) | THRATHRBRARBPLK1ALDH1A1 | |
| SCHEMBL18978069 | 0.76 | THRA (0.56) | THRATHRBRARBPLK1MEN1 | |
| SCHEMBL8995527 | 0.76 | PRSS1 (0.55) | THRATHRBRARBPLK1ALDH1A1 | |
| SCHEMBL15750344 | 0.75 | RARB (0.72) | THRATHRBRARBPLK1MEN1 | |
| SCHEMBL2564366 | 0.75 | RARB (0.67) | THRATHRBRARBPLK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125469-A1 | PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-11-04 | — | — | WO | disclosed |